It is a harsh irony that we have been conditioned to view whole wheat and other cereal grains as not only health food, but the very foundation of a healthy diet. Even more unfortunate, our federal agencies such as the USDA stand behind the consumption of wheat as if humans never thrived without it.
Unfortunately, cereal grains are a serious concern as both a source of carbohydrates (eaten in excess in the American diet) and as a source of toxic protein compounds. A little known but important fact is that wheat triggers gut inflammation in nearly everyone.
Cereal grains are the seeds of grasses and include wheat, corn, rice, barley, sorghum, oats, rye, and millet.
Grasses are for Grazers
Grasses evolved in concert with grazing mammals: both originated at the same time and they became common together. Grasses, unlike other plants, grow their leaves from the base rather than the tip so they are less likely to be damaged by grazing. Grasses evolved two innovations in order to reproduce successfully despite being regularly eaten. First they generate a multitude of seeds per plant – tens of thousands annually – so that many seeds can be eaten, as long as a few scatter and take root. This fecundity is what makes the grains so attractive for agriculture: much of the harvest can be consumed as food while still retaining plentiful seed for next year’s crop.
The second innovation was a set of toxic compounds specifically designed to sabotage the digestive tract of mammals. The plant’s strategy is to pass its seeds intact through the digestive tract of grazing animals so that they emerge (with fertilizer) to take root in a new location. (In other words, eating wheat causes large amounts of food to be excreted instead of digested in humans; for example, fecal weight increases 5.7 grams for every gram of wheat bran consumed (Cummings, 1993).)
Grazing mammals have evolved defenses for these toxins, such as digestive organs like rumens that allow for the brunt of toxins to be transformed by bacteria via fermentation. Humans, lacking such organs, are comparatively defenseless. (Ironically, this suggests that alcohol is a less toxic form of grain consumption because the grain’s toxins have been removed through fermentation.)
Grain Defenses are Toxic to Humans
Grain toxins are proteins and most abundant in the bran, but present in all parts of the kernel. White wheat flour is about 10% protein by weight, while crude wheat bran is about 16% protein by weight. With corn as a close second, wheat is the most toxic of the cereal grains with the following compounds being of most concern (i.e., there are others):
- Gluten, a compound protein that triggers autoimmune disease and promotes cancer, heart disease, and neuropathy.
- Opioids, which make wheat addictive and trigger schizophrenia.
- Wheat germ agglutinin, a protein that damages the intestine and interferes with vitamin D action, thus sabotaging the immune system and promoting chronic infections.
Gluten is directly toxic to intestinal cells by inhibiting cell proliferation, increasing cellular oxidation products, and changing membrane structure. In the body, gluten changes the structure of the intestine by reducing the height of villi, decreasing the depth of crypts, and decreasing enterocyte surface. In other words, gluten sabotages the gut, reduces it surface area, and impairs digestion.
Like all toxins, gluten inspires an immune response. This immune response helps to clear the gluten from the intestine thereby preventing build up of toxins, however in the process it makes the intestine inflamed. This immune response kills intestinal cells and makes the gut leaky.
There appear to be four levels of immune response to wheat:
- About 83% of the population develops observable gut inflammation after eating wheat gluten (Bernardo et al., 2007).
- About 30% of the population develops anti-wheat-gluten antibodies locally in the intestine (Guyenet).
- About 11% of the population develops systemic antibodies to wheat gluten.
- About 0.4% of the population develops systemic antibodies that attack human cells in the intestine, thyroid, pancreas, and elsewhere.
This last group is diagnosed with celiac disease. With the immune system attacking and killing gut cells, the intestine can be damaged to the point that sufferers have difficulty absorbing needed nutrients (Sollid and Jabri, 2005).
Leaky gut is a condition that occurs due to the development of gaps between the cells (enterocytes) that make up the membrane lining the intestinal wall. These tiny gaps allow substances such as undigested food, bacteria and metabolic wastes, that should be confined to the digestive tract, to escape into the bloodstream, hence the term leaky gut syndrome.
Once the integrity of the intestinal lining is compromised with a flow of toxic substances “leaking out” into the bloodstream, the body experiences significant increases in inflammation. Consequently, the immune system may become confused and begin to attack the body as if it were an enemy (autoimmune diseases).
Most often, leaky gut syndrome is associated with inflammatory bowel diseases like Crohn’s and ulcerative colitis, or celiac disease. However, even healthy people can have varying degrees of intestinal permeability leading to a wide variety of health symptoms that can be influenced heavily by the foods one chooses to eat.
Side note: Rice, even glutinous rice (e.g., sticky rice), does not contain gluten. Glutinous rice is sticky because of the structure of its starch. Glutinous rice does not contain gluten or other toxic proteins and is safe to eat.
Personal note: I admit I was at first resistant to this information because I love pasta and bread, but when I had a relapse of gut permeability in 2010, I was able to link it back to eating steel cut oats religiously every morning for about one year prior to the outbreak.
New Report Warns of the Sugar in Cereals Marketed to Kids
One of the most common ways grains are consumed is in the form of cereal, many of which are marketed to kids and adults as health foods. A new report from the Environmental Working Group (EWG) revealed that many popular children’s cereal brands contain more sugar than snack cakes and cookies. For instance, one cup of Kellogg’s Honey Smacks, which is nearly 56 percent sugar by weight, has more sugar than a Twinkie, while a one-cup serving of 44 other children’s cereals analyzed contain more sugar than three Chips Ahoy! cookies.
Sugar, like grains, can upset the balance of bacteria in the digestive tract, encouraging damage to the intestinal lining that can lead to leaky gut. In essence, sugary children’s cereals are a double-edged sword by assaulting the fragile gastrointestinal tract with both damaging sugar and grains. It may be worth considering offering children a healthier breakfast alternative.
Fermented Foods are the Antidote
Leaky gut can cause digestive symptoms such as bloating, gas and abdominal cramps, but it can also cause or contribute to many others, such as fatigue, skin rashes, joint pain, allergies, psychological symptoms, autism and more.
Leaky gut is a vicious cycle because once the digestive tract has been damaged, it allows various gut contents to flood into the bloodstream where they wreak havoc on health. The key to preventing and reversing leaky gut lies in eliminating pro-inflammatory foods in the diet, primarily sugars, grains, and oils high in Omega 6s (e.g., soy, corn, safflower oils) and introducing healthier foods to support beneficial gut bacteria. To restore gut health and prevent leaky gut from occurring, eating traditionally fermented foods is essential.
Fermented foods are essential because they provide probiotic microbes in the best possible form and will carry probiotic microbes all away down to the end of the digestive system. Fermentation predigests the food, making it easy for our digestive systems to handle, which is why fermented foods are easily digested by people with a damaged gut. Fermentation releases nutrients from the food, making them more bio-available for the body; for example, sauerkraut contains 20 times more bio-available vitamin C than fresh cabbage.
On Dr. Campbell-McBride’s web site (http://www.gaps.me/preview/?page_id=30) you can find recipes for many traditionally fermented foods, including sauerkraut, yogurt, kefir, kvass and more. Regularly eating fermented foods that have not been pasteurized (pasteurization kills the naturally occurring probiotics) allows healthy gut bacteria to thrive. Once gut flora is optimized, leaky gut symptoms will improve naturally provided the body is also supported with thoughtful dietary choices.
Personal note: I just finished eating my first home made batch of sauerkraut and I cannot believe what a positive difference it has made in such a short period. I eat a small amount with every meal, particularly with animal products (e.g., organic/ pastured eggs, meat, cheese). Oh, how I wish I had been eating home made sauerkraut 10 years ago when I was so sick from my own digestive disorders!
References
Bernardo D et al. 2007. Is gliadin really safe for non-celiac individuals? Production of interleukin 15 in biopsy culture from non-coeliac individuals challenged with gliadin peptides. Gut 56(6):889-90.
Cummings JH. 1993. The effect of dietary fibre on fecal weight and composition. In: Spiller GA, ed. Handbook of dietary fibre in human nutrition. 2nd ed. Boca Raton, FL: CRC Press, p.547-73.
Gluten composition: http://en.wikipedia.org/wiki/Gluten. Howdle PD. 2006. Gliadin, glutenin or both? The search for the Holy Grail in coeliac disease. Eur J Gastroenterol Hepatol 18(7):703-6.
Gut and Psychology Syndrome: http://gaps.me/preview/
Jaminet P, Jaminet, SC. 2010. Perfect Health Diet. Ying-Yang Press. Cambridge, MA.
Sollid LM, Jabri B. 2005. Is celiac disease an autoimmune disorder? Curr Opin Immunol 17(6):595-600.
Stephan Guyenet, http://high-fat-nutrition.blogspot.com/2008/05/gluten-links-from-bloggier.html, quoting Dr Kenneth Fine of EnteroLab; see transcript of Dr Fine’s talk at http://www.enterolab/StaticPages/EarlyDiagnosis.htm.
–Cygnia F. Rapp, Founder of Prosperity Organic Foods


